> Clive Slaughter, Ph.D.
Member, Molecular
Biotechnology
St. Jude Children's Research
Hospital
Contact Information
Clive Slaughter, Ph.D.
Hartwell
Center for Bioinformatics & Biotechnology
Molecular Biotechnology
Division
St. Jude Children's Research
Hospital
332 N. Lauderdale
Memphis, TN 38105-2794
Email: clive.slaughter@stjude.org
Phone: (901) 495-4844
Fax: (901) 495-2945
Education
Ph.D. - University College, London
Research Interests
Dr. Slaughter is currently Assistant Director of the Hartwell Center for Bioinformatics and Biotechnology at St. Jude Children's Research Hospital. He received his B.S. degree in Zoology from University College London in 1973, and his Ph.D. in Human Biochemical Genetics, also from University College London, in 1976. Following postdoctoral fellowships at the University of Pennsylvania and the University of Texas Southwestern Medical Center at Dallas, he held faculty appointments at Cold Spring Harbor Laboratory and University of Texas Southwestern Medical Center at Dallas before joining St. Jude as a Full Member in 2000.
Dr. Slaughter's principal interest is in the application of advanced analytical techniques for the analysis of protein chemical structure to the solution of problems in biomedicine. He has published over 164 research articles. His work since 1991 prior to moving to St. Jude focused on the mechanisms of intracellular protein turnover. His interests now encompass the study of the broad-scale changes in protein assemblages that ensue from cellular alterations in physiological or genetic state (proteomics). In these studies, mass spectrometric techniques play a dominant role.
Dr. Slaughter serves as Associate Editor of the Journal of Biomolecular Techniques, serves on NIH review panels, and holds a joint appointment in the Department of Molecular Sciences at the University of Tennessee at Memphis, where he teaches in he College of Medicine.
Selected Publications
van Oers NSC , Tohlen B, Malissen B, Moomaw CR, Afendis S, Slaughter CA . 2000. The 21- and 23-kD forms of TCR x are generated by specific ITAM phosphorylations. Nature Immunology 1:322-328.
Trembley JH, Hu D, Hsu L-C, Yeung C-Y, Slaughter C, Lahti JM, Kidd VJ. 2002. PITSLRE p110 protein kinases associate with transcription complexes and effect their activity . J. Biol. Chem. , 277:2589-2596.
Trembley JH, Hu D, Slaughter CA , Lahti JM, Kidd VJ. 2002. Casein kinase 2 interacts with cyclin-dependent kinase11 in vivo and phosphorylates both the RNA polymerase II carboxy-terminal domain and CDK11 in vitro. J. Biol. Chem . 278:2265-2270.
Bencsath
KP, Podgorski M, Meluh PB, Pagala VR, Slaughter CA , Schulman
BA. (2002) Identification of a multifunctional binding site
on Ubc9p required for Smt3p conjugation. J. Biol. Chem. 49:47938-47945.
