> Clayton Naeve, Ph.D.
Director, Hartwell Center for Bioinformatics & Biotechnology
Member and Chief, Molecular Biotechnology
Chief Research Information Officer
Contact Information
Clayton W. Naeve, Ph.D.
Hartwell Center for Bioinformatics & Biotechnology
St. Jude Children's Research
Hospital
332 N. Lauderdale
Memphis, TN 38105-2794
Email: clayton.naeve@stjude.org
Phone: (901) 495-3689
Fax: (901) 495-2945
Education
PhD - Colorado State University
Research Interests
- Bioinformatics
- High-throughput biotechnologies
Dr. Naeve is Director of the Hartwell Center for Bioinformatics & Biotechnology at St. Jude Children's Research Hospital where he also serves as Chief of Molecular Biotechnology and as Chief Research Information Officer for St. Jude. He received B.S. and M.S. degrees (Microbiology) from South Dakota State University and his Ph.D. (Virology & Cell and Molecular Biology) from Colorado State University in 1977. Following a postdoctoral fellowship at the University of Utah he joined the Virology & Molecular Biology department at St. Jude in 1980. For the past 20 years Dr. Naeve has actively deployed emerging biotechnologies and bioinformatics resources in support of all St. Jude research programs; examples include automated DNA synthesis and DNA sequencing, automated peptide synthesis and protein sequencing, mass spectrometry, DNA microarray technologies, and proteomics capabilities. Dr. Naeve launched bioinformatics at SJCRH in 1989 and his staff has subsequently brought outstanding bioinformatics resources to St. Jude in the form of applications, databases, computing environment, and expert support. This group has also played a key role in building an appropriate infrastructure to support these research activities including bringing the Internet, email, the web, and high-performance computing to St. Jude. Through major expansion efforts the Center has grown to a staff of 68 including 25 Ph.D.s. The Hartwell Center is unique in integrating these technologies and providing St. Jude with world-class scientific resources and tools to facilitate discovery. In 1999, , Dr. Naeve was appointed Chief Research Information Officer for St. Jude and in 2001, he established Research Computing at SJCRH, expanding bioinformatics to include a Client Services group that now provides desktop support to the research community at SJCRH. Dr. Naeve also serves as Chief of Molecular Biotechnology, an academic department designed to conduct applied research and to advance the biotechnologies contained within the Hartwell Center.
Dr. Naeve has served on numerous NIH and NCI review panels, was Editor-in-chief of the Journal of Biomolecular Techniques published by the Association of Biomolecular Resource Facilities (ABRF) and has served on numerous ABRF committees. Dr. Naeve has published over 70 research articles and book chapters. He is a Board member of the Tennessee Biotechnology Association, a member of the Feinstone Center for Genomic Research at the University of Memphis, a member of the External Advisory Board for Barbara Ann Karmanos Cancer Institute, the University of Mississippi Bioinformatics Undergraduate Program, and a member of the Scientific Advisory Board for Transnetix, Inc. He is Associate Professor, Department of Pathology, University of Tennessee Health Science Center and serves as a consultant for the United States Air Force.
Selected Publications
Yeoh, Eng-Juh, Ross, Mary E., Shurtleff, Sheila A., Williams, Kent W., Patel, Divyen, Mahfouz, Rami, Behm, Fred G., Raimondi, Susana C., Relling, Mary V., Patel, Anami, Cheng, Cheng, Campana, Dario, Wilkins, Dawn, Zhou, Xiaodong, Li, Jinyan, Liu, Huiqing, Pui, Ching-Hon, Evans, William E., Naeve, Clayton , Wong, Limsoon, Downing, James R. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell (1-2):133-143, 2002.
Kuefer, Martin U., Chinwalla, Vandana, Zeleznik-Le, Nancy J., Behm, Frederick G., Naeve, Clayton W ., Rakestraw, Karen M., Raimondi, Susana C., Morris, Stephan W. Characterization of the MLL Partner Gene, AF15q14, involved in the t(11;15)(1q23;q14-15). Oncogene 22:1418-1424, 2003.
Cheok M.H., Yang W., Pui C., Downing J.R., Cheng C., Naeve C.W. , Relling M.V., Evans W.E. Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells, pp. 85-90, Nature Genetics , 2003.
